In vitro interaction between clindamycin and trimethoprim in combination on staphylococci.

Autor: el-Baz W; Department of Medicine, Ain-Shams University, Cairo, Egypt., Abd-el Hamid T, Tantawi A, Sabbour MS
Jazyk: angličtina
Zdroj: International journal of clinical pharmacology research [Int J Clin Pharmacol Res] 1993; Vol. 13 (3), pp. 187-92.
Abstrakt: The in-vitro interaction between clindamycin and trimethoprim was tested on 10 staphylococcal clinical isolates by the checkerboard technique and by the time-kill curve. Indifference was demonstrated against seven of these strains and antagonism against three. The clindamycin/trimethoprim combination is of no value if the purpose of the combination is to obtain synergy against staphylococci. However, the combination is useful against mild polymicrobial infections due to Gram-positive aerobes, anaerobes and Enterobacteriaceae.
Databáze: MEDLINE