| Autor: |
Cruz Jdos S; Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan., Matsuda H |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1993 Aug 03; Vol. 239 (1-3), pp. 223-6. |
| DOI: |
10.1016/0014-2999(93)90999-x |
| Abstrakt: |
The effects of arenobufagin, a bufadienolide isolated from toad venom, on the Na+/K+ pump were investigated by recording the whole-cell current of dissociated cardiac myocytes. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1. Arenobufagin is 3.5-fold more potent than ouabain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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