| Autor: |
Lien YH; Department of Medicine, University of Arizona Health Sciences Center, Tucson 85724., Hansen R, Kern WF, Bangert J, Nagle RB, Ko M, Siskind MS |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 1993 Oct; Vol. 22 (4), pp. 598-602. |
| DOI: |
10.1016/s0272-6386(12)80936-x |
| Abstrakt: |
Ciprofloxacin is known to cause acute interstitial nephritis. We report the first case of ciprofloxacin-induced granulomatous interstitial nephritis and localized elastolysis. The patient presented with acute renal failure and skin lesions following a 14-day course of ciprofloxacin administered for cellulitis. The patient had symmetric, palm-sized, tender violaceous plaques on both axillae. The renal biopsy revealed granulomatous interstitial disease. A skin biopsy revealed an elastolytic process with histocytic infiltration and calcification. After discontinuing ciprofloxacin and starting a short course of steroid therapy, the skin lesion and renal function improved promptly. The nephritis relapsed after prednisone was discontinued and responded to a second course of steroid therapy. Ciprofloxacin, like penicillin, can cause granulomatous interstitial nephritis and elastolysis. A prolonged course of steroid therapy may be indicated in patients with ciprofloxacin-induced granulomatous interstitial nephritis to avoid early relapse. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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