Exacerbation of psoriasis due to interferon-alpha treatment of chronic active hepatitis.

Autor: Georgetson MJ; Department of Gastroenterology and Hepatology, Guthrie Clinic, Sayre, Pennsylvania., Yarze JC, Lalos AT, Webster GF, Martin P
Jazyk: angličtina
Zdroj: The American journal of gastroenterology [Am J Gastroenterol] 1993 Oct; Vol. 88 (10), pp. 1756-8.
Abstrakt: Interferon-alpha is an immune modulating drug which is indicated for the treatment of chronic viral hepatitis B and C. Several previous reports have suggested an association between treatment of patients with interferon-alpha and the development or exacerbation of autoimmune diseases. We report two patients with chronic viral hepatitis in whom treatment with interferon-alpha was associated with dramatic worsening of previously diagnosed psoriasis, necessitating discontinuation of the drug.
Databáze: MEDLINE