Treatment of bacterial vaginosis with a three day course of 2% clindamycin vaginal cream: a pilot study.
| Autor: | Dhar J; University Department of Genito-Urinary Medicine, Royal Liverpool University Hospital, UK., Arya OP, Timmins DJ, Moss S, Mukembo S, Alawattegama AB, Williams O |
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| Jazyk: | angličtina |
| Zdroj: | Genitourinary medicine [Genitourin Med] 1994 Apr; Vol. 70 (2), pp. 121-3. |
| DOI: | 10.1136/sti.70.2.121 |
| Abstrakt: | Objective: To evaluate the efficacy and safety of a 3 day course of 2% clindamycin cream in the treatment of bacterial vaginosis. Design: A prospective, randomised, double blind, placebo controlled study. Setting: Department of Genitourinary Medicine, Royal Liverpool University Hospital. Subjects: 55 female patients aged 18 years and over, and premenopausal, who spontaneously or after questioning complained of symptoms of bacterial vaginosis. Results: 55 patients were enrolled. 44 patients were evaluable at Visit 1 when among the 23 who received clindamycin cream bacterial vaginosis was not present in 22 (95.6%) and only one failed treatment. Of the 21 patients in the placebo group only one (4.8%) patient was cured and 20 (95.2%) were failures. Of the 17 patients evaluable at Visit 2 in the clindamycin group, bacterial vaginosis was not present in 14 (82.4%) and had recurred in three. No serious adverse events were noted in either group. Conclusion: This pilot study provides encouraging evidence of the efficacy and safety of a 3 day course of 2% clindamycin cream in bacterial vaginosis. |
| Databáze: | MEDLINE |
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