Impact of compliance and side effects on the clinical outcome of patients treated with oral erythromycin.

Autor: Anastasio GD; Department of Family Practice, Carolinas Medical Center, Charlotte, NC 28232-2861., Little JM Jr, Robinson MD, Pettice YL, Leitch BB, Norton HJ
Jazyk: angličtina
Zdroj: Pharmacotherapy [Pharmacotherapy] 1994 Mar-Apr; Vol. 14 (2), pp. 229-34.
Abstrakt: Study Objective: To determine the relationship among compliance, side effects, and self-reported outcome for patients in an erythromycin trial.
Design: A retrospective analysis of data from a multicenter, prospective, single-blind, randomized trial.
Setting: Five metropolitan ambulatory care offices.
Patients: The 252 adults (> 18 yrs) were prescribed oral erythromycin 1.0 g/day (base equivalent) for infectious disorders.
Intervention: Subjects received erythromycin for 10 days and reported compliance, drug efficacy, and side effects in a daily diary. Compliance was measured by tablet count.
Results: A negative correlation was found between gastrointestinal symptom severity score and percentage of tablets taken (p < 0.001). A significant positive correlation was seen between compliance and outcome (p < 0.001). Subjects who took greater than 80% of the drug achieved the treatment goal more frequently than those taking 80% or less (94% vs 59%, p < 0.001).
Conclusions: Side effects of erythromycin adversely affected compliance. Compliance had a positive effect on self-reported outcome.
Databáze: MEDLINE
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