| Autor: |
Fiorio R; Istituto di Mutagenesi e Differenziamento, C.N.R., Pisa, Italy., Morichetti E, Vellosi R, Bronzetti G |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 1993 Jul-Sep; Vol. 12 (3), pp. 139-42. |
| Abstrakt: |
Humans are exposed daily to electromagnetic fields (EMFs) originating from a variety of devices and systems. During the 1980s many reports of potential mutagenic, teratogenic, and carcinogenic effects of EMFs were published, sometimes with contrasting results. To date, no study has established unequivocally a causal relationship between EMFs and cancer. Cell cultures can provide a simple and inexpensive tool for the study of the effects of EMFs. We have used the Chinese hamster V79 cell line to evaluate the influence of a sinusoidal EMF at 50-Hz with a constant flow of 2 G on the induction of HGPRT- mutants and on survival. Our results showed that the EMF employed did not induce any modification of mutation frequency, but the results on survival were contrasting. When only 10(2) cells were plated, a reduction in the number of colonies, reaching about 50% after 10 days of treatment, was observed; however, when 2 x 10(5) cells or more were seeded, no reduction in viability was recorded. An intercellular metabolic interaction may explain these results. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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