An inflammatory eruption associated with recombinant human IL-6.

Autor: Fleming TE; Department of Dermatology, University Hospitals of Cleveland, Ohio 44106., Mirando WS, Soohoo LF, Cooper BW, Zaim MT, Lazarus HM, Elmets CA
Jazyk: angličtina
Zdroj: The British journal of dermatology [Br J Dermatol] 1994 Apr; Vol. 130 (4), pp. 534-6.
DOI: 10.1111/j.1365-2133.1994.tb03393.x
Abstrakt: Interleukin 6 (IL-6) is an endogenous cytokine with multiple biological functions, including amplification of the inflammatory response. Recombinant human IL-6, administered as part of a chemotherapeutic regimen, has recently been shown to cause regression of certain types of malignant tumours. We report a patient who developed a cutaneous eruption consisting of coalescent, erythematous, scaling macules and papules after administration of recombinant human IL-6, given as part of her chemotherapy for ductal carcinoma of the breast.
Databáze: MEDLINE