| Autor: |
Fedotcheva NI, Skarga IuIu, Foĭgel' AG |
| Jazyk: |
ruština |
| Zdroj: |
Biokhimiia (Moscow, Russia) [Biokhimiia] 1994 Mar; Vol. 59 (3), pp. 419-24. |
| Abstrakt: |
It has been shown that the increase of the membrane potential in uncoupled brown fat mitochondria after addition of 1-2 mM GDP to a medium containing potassium acetate is accompanied by swelling of mitochondria which occurs in two phases. The first swelling phase is due to the electrogenic transport of K+ ions, while the second one is activated by carboxyatractylate and carnitine. The swelling is practically completely inhibited by a further rise of the GDP concentration irrespective of high values of the membrane potential. Unlike K+ transport, the potential-dependent transport of Na+ ions occurs more rapidly, is monophasic and insensitive to carboxyatractylate and carnitine. It is suggested that regulation of K+ ion transport in brown fat mitochondria is mediated by the action of nucleotides and fatty acid esters on the uncoupling protein and ADP/ATP antiporter. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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