| Autor: |
Sutherland WH; Department of Medicine, University of Otago Medical School, Dunedin, New Zealand., Lewis-Barned NJ, Pratt MC, Tillman HC, Walker RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1994 Jan; Vol. 83 (1), pp. 77-86. |
| Abstrakt: |
The effect of acute hyperinsulinemia on plasma lipoprotein a [Lp(a)] concentration in 25 patients with non-insulin dependent diabetes mellitus (NIDDM) and in 10 healthy subjects was examined. Insulin was infused into the subjects for 2 hours while baseline plasma glucose concentrations were maintained. Plasma Lp(a) levels showed a small but significant mean (+/- SD) increase in NIDDM patients (12 +/- 26 U/l, p < 0.01) but did not vary significantly in healthy subjects (3 +/- 15 U/l) when insulin was infused. There was considerable individual variation (-35 to 98 U/l) in the response of Lp(a) to acute hyperinsulinemia and the response was correlated significantly with baseline Lp(a) levels (r = 0.399, p < 0.05). These data suggest that acute hyperinsulinemia at constant baseline glucose levels may raise plasma Lp(a) levels in NIDDM patients more particularly in those with high initial Lp(a) concentrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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