| Autor: |
Lewin AH; Research Triangle Institute, Research Triangle Park, North Carolina 27709., Bos ME, Zusi FC, Nair X, Whiting G, Bouquin P, Tetrault G, Carroll FI |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmaceutical research [Pharm Res] 1994 Feb; Vol. 11 (2), pp. 192-200. |
| DOI: |
10.1023/a:1018938920796 |
| Abstrakt: |
Evaluation of 13-cis-12-substituted analogues of retinoic acid in a series of dermatologic screens has revealed that structural modifications can lead to selectivity and specificity. An analogue, 11-cis,13-cis-12-hydroxymethylretinoic acid, delta-lactone, has been found to have good activity and to be devoid of topical and systemic toxicity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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