[The immunogenic properties and prophylactic efficacy of a live polyvalent influenza vaccine in children 5 to 14 years old].

Autor: Grigor'eva EP, Rekstin AR, Rudenko LG, Ramirez A, Barro M, Lisovskaia KV, Klimov AI, Aleksandrova GI
Jazyk: ruština
Zdroj: Voprosy virusologii [Vopr Virusol] 1994 Jan-Feb; Vol. 39 (1), pp. 26-9.
Abstrakt: Production lots of a live influenza vaccine made of strains A/47/T (N1H1), A/47/6/2 (H3N2), and B/60/32 were used for vaccination of 3663 children aged from 5 to 14 years inoculated twice with monovaccines, a trivaccine made of the above strains, or placebo. Both mono- and polyvaccine were practically areactogenic. An average per cent of subjects with a significant rise in antibody titres to the respective three antigens was 60%. The efficacy of the vaccination was 31.0-42.8% for monopreparations and 36.3% for the trivaccine. The studies showed the possibility and expedience of using for children the live influenza vaccine in the form of a polyvalent preparation including current influenza type A and B viruses.
Databáze: MEDLINE