HLA antigens in Arab children with steroid-responsive nephrotic syndrome.

Autor: Zaki M; Department of Paediatrics, Farwania Hospital, Kuwait., Daoud AS, al Saleh QA, al Najedi AK, White AG
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 1994 Feb; Vol. 8 (1), pp. 74-5.
DOI: 10.1007/BF00868269
Abstrakt: Forty-eight Arab patients with steroid-responsive childhood nephrotic syndrome were studied for the frequency of HLA-A, -B, -C and -DR antigens. HLA-DR7 was significantly increased in the patient group (63% vs. 28%, P = 0.0002) confirming reports of a DR7 association in other ethnic groups and indicating a universal association with this antigen. HLA-CW6 was also significantly increased (44% vs. 21%, P corr. = 0.042). HLA-DQW1 was significantly reduced in the patients (29% vs. 57%, P corr. = 0.012) as was HLA-CW4 (6% vs. 24%, P corr. = 0.042).
Databáze: MEDLINE