| Autor: |
Emilie D; INSERM U131, Clamart, France., Leger-Ravet MB, Devergne O, Raphael M, Peuchmaur M, Coumbaras J, Crevon MC, Galanaud P |
| Jazyk: |
angličtina |
| Zdroj: |
Leukemia & lymphoma [Leuk Lymphoma] 1993 Nov; Vol. 11 (5-6), pp. 411-7. |
| DOI: |
10.3109/10428199309067934 |
| Abstrakt: |
Interleukin-6 is a major B lymphocyte growth factor, and may play a role in the proliferation of malignant B lymphocytes. In order to provide arguments supporting such a role, the intratumoral production of IL-6 was studied by in situ hybridization and immunohistochemistry in 53 neoplastic tissues from B cell chronic lymphocytic leukemia or B lymphomas. IL-6-producing cells were detected in all samples but 5. However, the number of IL-6 producing cells was variable amongst the different cases. Increased density of IL-6-producing cells was highly dependent on the presence of malignant immunoblasts within the neoplastic clone. IL-6 was produced in a paracrine way, macrophages and endothelial cells being the main producers of the cytokine while malignant immunoblasts expressed the IL-6 receptor. Taken together, these results suggest that IL-6 may indeed act as a growth factor for malignant cells in some B lymphoproliferations and that this paracrine loop could be the target of new therapeutic approaches. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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