| Autor: |
Sabesin SM, Kuiken LB, Ragland JB |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1975 Dec 26; Vol. 190 (4221), pp. 1302-4. |
| DOI: |
10.1126/science.812181 |
| Abstrakt: |
Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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