[Liver cell necrosis during administration of clozapine].

Autor: Hovens JE; Psychiatrisch Ziekenhuis H.C. Rümke groep, locatie Zeist., Vogtländer LM, Verhoeve HA, Thunnissen PL
Jazyk: Dutch; Flemish
Zdroj: Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 1994 Feb 12; Vol. 138 (7), pp. 363-5.
Abstrakt: A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.
Databáze: MEDLINE