| Autor: |
Silberstein CH; Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467., O'Dowd MA, Chartock P, Schoenbaum EE, Friedland G, Hartel D, McKegney FP |
| Jazyk: |
angličtina |
| Zdroj: |
General hospital psychiatry [Gen Hosp Psychiatry] 1993 Nov; Vol. 15 (6), pp. 351-9. |
| DOI: |
10.1016/0163-8343(93)90001-5 |
| Abstrakt: |
The evolution of central nervous system (CNS) impairments associated with human immunodeficiency virus (HIV) infection was assessed by a prospective, longitudinal study of patients in a methadone maintenance clinic. At a mean of 47 months after baseline testing, which included physical exams, HIV antibody testing and a neuropsychological (NP) screening battery, 121 subjects received a second NP assessment. Forty subjects (33%) who were seropositive at baseline showed statistically significant declines in NP function over the 4 years compared with 81 seronegatives, on the Finger Tapping and Trail Making B tests. This relatively long-term follow-up suggests that subtle cognitive deficits develop over time and can be identified early, but their course is slow and appears generally to parallel that of non-CNS symptoms/signs of HIV infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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