| Autor: |
Burger H; Department of Medical Oncology, Dr. Daniel den Hoed Cancer Center/Dijkzigt University Hospital Rotterdam, The Netherlands., Mostert MC, Kok EM, Wagemaker G, Dorssers LC |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1994 Mar 01; Vol. 1217 (2), pp. 195-8. |
| DOI: |
10.1016/0167-4781(94)90034-5 |
| Abstrakt: |
Interleukin-3 (IL-3) genes were cloned from chimpanzee (Pan troglodytes), tamarin (Saguinus oedipus) and marmoset (Callithrix jacchus) and expressed in COS cells. Although the IL-3 gene structure is well conserved in these primate species, sequence analysis revealed extensive base substitutions. The chimpanzee IL-3 protein, which is highly homologous (98.5% identity) to human IL-3, stimulated proliferation of human cells dependent on IL-3. In contrast, due to the numerous amino acid substitutions in the New World monkey IL-3 species, no stimulation of human cells was observed, illustrating the extensive evolutionary divergence of IL-3. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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