| Autor: |
Zhang L; Department of Biological Sciences, Kent State University, OH 44242., Dorman RV |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research bulletin [Brain Res Bull] 1993; Vol. 32 (4), pp. 437-41. |
| DOI: |
10.1016/0361-9230(93)90212-t |
| Abstrakt: |
Both the activation of protein kinase C (PKC) and the facilitation of depolarization-evoked glutamate release have been implicated in the induction of hippocampal long-term synaptic potentiation. These observations may be functionally related, since stimulation of PKC activity enhances evoked glutamate release. Recently, it was shown that arachidonic acid and the diacylglycerol analog oleoyl-acetyl-glycerol activate brain PKC in a synergistic fashion. We report the facilitation of depolarization-induced glutamate efflux from hippocampal mossy fiber synaptosomes due to a combination of arachidonic acid and oleoyl-acetyl-glycerol. The potentiating effects appeared to depend on the activation of PKC since they were attenuated by staurosporine. In addition, the effects of arachidonic acid and oleoyl-acetyl-glycerol appeared to be limited to calcium-dependent processes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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