| Autor: |
Aneiros A; Instituto de Investigaciones Fundamentales del Cerebro, La Habana, Cuba., García I, Martínez JR, Harvey AL, Anderson AJ, Marshall DL, Engström A, Hellman U, Karlsson E |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1993 May 07; Vol. 1157 (1), pp. 86-92. |
| DOI: |
10.1016/0304-4165(93)90082-j |
| Abstrakt: |
A peptide toxin affecting potassium channels was isolated from the sea anemone Bunodosoma granulifera. It facilitates acetylcholine release at avian neuromuscular junctions, competes with dendrotoxin I, a probe for voltage-dependent potassium channels, for binding to synaptosomal membranes of rat brain with a Ki of 0.7 nM and suppresses K+ currents in rat dorsal root ganglion neurones in culture. It represents a new structural type of potassium channel toxin with the sequence V1RCDWFKETA10CRHAKSLGNC20RTSQKYRANC30AKTLQCC37 (M(r) 4275, three disulfides). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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