| Autor: |
al Badri AM; Department of Pathology, Royal Infirmary, Glasgow, UK., Foulis AK, Todd PM, Gariouch JJ, Gudgeon JE, Stewart DG, Gracie JA, Goudie RB |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pathology [J Pathol] 1993 Feb; Vol. 169 (2), pp. 203-6. |
| DOI: |
10.1002/path.1711690205 |
| Abstrakt: |
The relationship between damage to cutaneous melanocytes and antimelanocyte autoimmunity in vitiligo is unclear. We have demonstrated abnormal expression of MHC class II molecules by perilesional melanocytes in 13/21 patients with vitiligo and a six-fold increase in the number expressing the intercellular adhesion molecule ICAM-1. These molecules have important roles in normal antigen presentation and activation of helper T lymphocytes, and their expression by melanocytes may contribute to the abnormal immune response in vitiligo. MHC class II is not expressed by melanocytes in psoriasis and is unlikely to be induced in vitiligo by cytokines released from activated non-melanocyte-specific T lymphocytes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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