| Autor: |
Osman AM; Cancer Biology Department, National Cancer Institute, Cairo, Egypt., Saad SF, Saad SY, el-Aaser AB, el-Merzabani MM |
| Jazyk: |
angličtina |
| Zdroj: |
Chemotherapy [Chemotherapy] 1994 Jul-Aug; Vol. 40 (4), pp. 227-31. |
| DOI: |
10.1159/000239197 |
| Abstrakt: |
The pharmacokinetics of two commonly used anticancer drugs, methotrexate (MTX) and 5-fluorouracil (5-FU), were investigated in normal and bilharzial-infested mice. Liver glucose-6-phosphatase activity and antipyrine clearance were used as parameters of liver function. Liver glucose-6-phosphatase activity was significantly reduced in bilharzial-infested mice compared with the normal controls. Bilharzial infestation caused a significant reduction in the elimination (beta) and clearance rate (Cl) of antipyrine, whereas its elimination half-life (t1/2 beta) was increased in comparison with the normal controls. A similar pattern was also obtained after MTX and 5-FU administration in bilharzial mice, compared to controls. These results indicate that hepatic bilharziasis causes a significant reduction in the hepatic clearance and elimination of MTX and 5-FU, whereas their areas under the concentration-time curve were significantly increased. These findings may have to be considered in the treatment of bilharzial cancer patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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