| Autor: |
Galoyan AA; Department of Neurohormone Biochemistry, Academy of Sciences of Armenia, Yerevan., Abrahamian GE, Chailyan SG, Hashim GA, Lajtha A |
| Jazyk: |
angličtina |
| Zdroj: |
Neurochemical research [Neurochem Res] 1994 Apr; Vol. 19 (4), pp. 451-6. |
| DOI: |
10.1007/BF00967323 |
| Abstrakt: |
A fragment (11-19) of thymosin beta 4 was found to stimulate phosphodiesterase activity even in the absence of calcium and calmodulin. Half-maximal enzyme activation occurred with 10 nM peptide, and was further increased by phospholipids such as phosphatidylserine. The mechanism of stimulation is an increase in the Vmax of cAMP degradation without a substantial change in the Km for the substrate. In the presence of calcium ions and calmodulin the peptide was also stimulatory. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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