| Autor: |
Willekes C; Department of Obstetrics, School of Midwifery, Kerkrade, The Netherlands., Roumen FJ, van Elsacker-Niele AM, Weiland HT, Vermey-Keers C, van Krieken JH, De Die-Smulders CE, Hamers GJ, Vaes-Peters GP |
| Jazyk: |
angličtina |
| Zdroj: |
Prenatal diagnosis [Prenat Diagn] 1994 Mar; Vol. 14 (3), pp. 181-5. |
| DOI: |
10.1002/pd.1970140307 |
| Abstrakt: |
In a case of hydrops fetalis, serological examination showed a recent maternal human parvovirus B19 infection. Amniocentesis revealed a unique unbalanced translocation between chromosomes 3 and 11 of the fetus. The mother proved to have a balanced reciprocal translocation between chromosomes 3 and 11. A grossly macerated hydropic male fetus was delivered with a flat nose and low implanted deformed ears. Histopathological examination revealed nuclear inclusion bodies in fetal erythroid cells, confirming human parvovirus B19 infection. Parvovirus B19 DNA was demonstrated by in situ hybridization in the nuclei of heart muscle cells. Our finding of two different disorders in one case illustrates the importance of a complete evaluation of every case of hydrops fetalis, especially concerning counselling on the outcome of future pregnancies. The human parvovirus B19 infection will not recur due to the acquired immunity of the mother, whereas the balanced reciprocal translocation will endanger future pregnancies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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