| Autor: |
Zimmerman RA, Klesius PH, Krushak DH, Mathews JH |
| Jazyk: |
angličtina |
| Zdroj: |
Canadian journal of comparative medicine : Revue canadienne de medecine comparee [Can J Comp Med] 1975 Apr; Vol. 39 (2), pp. 227-30. |
| Abstrakt: |
The effect of oral and parenteral penicillin on the development of cellular and humoral immune responses in chimpanzees infected with group A streptococcal M-types 1, 5 and 12 was investigated. The interrelationship between type-specific antibody response and enhancement of phagocytic competence of polymorphonuclear neutrophils was documented. Penicillin depressed or suppressed type-specific antibody response depending on the mode and dose of administration, probably because of its effect on the streptococci responsible for antibody stimulation. Penicillin was not demonstrated to have a direct effect on phagocytic ability in vitro. Therefore the primary effect of antibiotic therapy is the indirect relationship to suppression or inhibition of type-specific antibody response to M-protein which results in a diminution of phagocytic competence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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