Risk factors for bronchopulmonary dysplasia after extracorporeal membrane oxygenation.
| Autor: | Kornhauser MS; Department of Pediatrics, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pa., Cullen JA, Baumgart S, McKee LJ, Gross GW, Spitzer AR |
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| Jazyk: | angličtina |
| Zdroj: | Archives of pediatrics & adolescent medicine [Arch Pediatr Adolesc Med] 1994 Aug; Vol. 148 (8), pp. 820-5. |
| DOI: | 10.1001/archpedi.1994.02170080050008 |
| Abstrakt: | Objective: To determine risk factors for the development of bronchopulmonary dysplasia (BPD) after treatment with extracorporeal membrane oxygenation (ECMO). Design: Retrospective case-control study. Setting: Tertiary care level 3 neonatal intensive care unit. Participants: Seventy-three newborns treated with ECMO for severe respiratory failure during a 5-year period, who survived until day of life 28, and who did not have pulmonary hypoplasia as the initial cause for respiratory failure. Interventions: None. Main Outcome Measure: The presence of BPD after treatment with ECMO, which was defined as oxygen and/or ventilatory requirements at day of life 28, with characteristic abnormalities seen on chest x-ray film. Results: The age at ECMO initiation was significantly greater for patients with BPD compared with patients without BPD (mean +/- SD, 135 +/- 68 hours vs 50 +/- 37 hours; P < .001). There was an 11.5-fold increased risk for the development of BPD if ECMO was initiated at greater than 96 hours of age. The primary diagnosis of respiratory distress syndrome imparted a 5.2-fold increased risk for the development of BPD. Patients with BPD required ECMO significantly longer than patients without BPD (203 +/- 73 hours vs 122 +/- 51 hours; P < .001). Conclusion: These results demonstrate that delayed use of ECMO in treating neonatal respiratory failure is associated with an increased risk for the development of BPD and a longer duration of ECMO therapy. |
| Databáze: | MEDLINE |
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