| Autor: |
Yamamoto K; Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, Japan., Sawada Y, Iga T |
| Jazyk: |
angličtina |
| Zdroj: |
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1994 Jul; Vol. 17 (7), pp. 944-7. |
| DOI: |
10.1248/bpb.17.944 |
| Abstrakt: |
The relationship between the concentration of ambenonium (AMB), a selective and reversible acetylcholinesterase (AChE) inhibitor, in plasma and the potentiation of contractile muscle tension was investigated using a sciatic nerve-muscle preparation of rat. The developed isometric contraction was enhanced dose-dependently after i.v. administration of low doses (5-20 nmol/kg) of AMB, but the contraction was weakened when AMB was administered at high doses (100-1000 nmol/kg), and the concentration-effect relationship was bell-shaped. The muscle contraction profile after 50 nmol/kg administration without previous administration, with 20 nmol/kg and with 50 nmol/kg administered previously were quite different from each other. These findings suggest that the potentiation of contractile muscle tension by AMB may be acutely tolerated and the concentration-effect relationship may change time-dependently. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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