| Abstrakt: |
The author suggests a new method for the assessment of the bactericidal activity of local tissues in the treatment of bone fractures or after effects thereof by the transosseous osteosynthesis methods. Tissue components may induce the formation of large sites of delayed growth in standard Micrococcus lysodeikticus cultures. To assess the bactericidal activity of the tissues, a standard diagnostic disk with an antibiotic is placed onto such cultures, this permitting the expression of the tissue bactericidal activity in equivalents of the antibiotic antibacterial effect and determine the low, medium, and high levels of the tissue bactericidal activity with respect to the minimal therapeutic suppressing concentration of this antibiotic. The author suggests that the mechanism of a drastic elevation of the local tissue bactericidal activity in transosseous osteosynthesis is explained by an essential enhancement of local tissue metabolism. |
