Acute peripheral arterial occlusion: predictors of success in catheter-directed thrombolytic therapy.

Autor:	Ouriel K; Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642-8410., Shortell CK, Azodo MV, Guiterrez OH, Marder VJ
Jazyk:	angličtina
Zdroj:	Radiology [Radiology] 1994 Nov; Vol. 193 (2), pp. 561-6.
DOI:	10.1148/radiology.193.2.7972780
Abstrakt:	Purpose: To determine predictors of clot dissolution in patients undergoing catheter-directed urokinase thrombolysis for peripheral arterial occlusion (PAO). Materials and Methods: The study included 103 patients with limb-threatening symptoms of embolism lasting 14 days or less and resulting from embolism (n = 20) or thrombosis (n = 83). Successful lysis was defined as restitution of antegrade flow with less than 20% diameter reduction by residual thrombus. Stepwise logistic regression was used to analyze the data. Results: Relevant clinical variables were diabetic status (odds ratio, 0.75; P = .04 for diabetic patients), conduit type (1.25; P = .04 for native artery and 1.51; P = .02 for prosthetic graft), and number of arterial segments involved (1.60; P = .02 for one level and 1.42; P = .03 for two levels). Important procedural variables included intrathrombus positioning of catheter ports (odds ratio, 7.40; P = .001) and guide wire passage through the occlusion (3.10; P = .003). Absolute thrombus volume was nonpredictive but correlated with reperfusion time (P = .02) and infusion time (P = .01). Conclusion: Predictive parameters may help in the selection of candidates with PAO for thrombolytic therapy.
Databáze:	MEDLINE
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