Underrecognized postdosing reactions to methotrexate in patients with rheumatoid arthritis.
| Autor: | Halla JT; Division of Rheumatology, University of South Alabama College of Medicine, Mobile., Hardin JG |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of rheumatology [J Rheumatol] 1994 Jul; Vol. 21 (7), pp. 1224-6. |
| Abstrakt: | Objective: To report previously underrecognized postdosing side effects of methotrexate (MTX). Methods: Over a one and a half year period, in 2 practices, all patients with rheumatoid arthritis (RA) receiving weekly MTX, and volunteering symptoms within a few hours of MTX dosing were carefully questioned concerning the nature of the postdosing reaction. Results: Of 356 patients, 36 (10%) reported a previously underemphasized postdosing reaction consisting of arthralgias/myalgias, fatigue/malaise or both. Sixteen patients discontinued MTX primarily because of this side effect. Conclusion: In these patient populations, postdosing reactions were the 2nd most common side effect (after gastrointestinal) leading to MTX withdrawal. |
| Databáze: | MEDLINE |
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