| Autor: |
Sánchez FO; Laboratorio Central de Investigaciones, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Rodríguez JI, Agudelo G, García LF |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 1994 Dec; Vol. 62 (12), pp. 5673-8. |
| DOI: |
10.1128/iai.62.12.5673-5678.1994 |
| Abstrakt: |
The aim of the present study was to determine the profile of immune responsiveness that differentiates patients with tuberculosis (TB) from healthy tuberculin-positive controls. Forty-five patients with pulmonary TB and 16 healthy tuberculin-positive controls, all human immunodeficiency virus negative, were studied. Patients had decreased reactivity to tuberculin, diminished proliferative response to purified protein derivative (PPD), lower concentrations of interleukin-2 (IL-2) and gamma interferon in PPD-stimulated cultures, no increase in the percentage of gamma/delta cells in PPD-stimulated cultures, and higher immunoglobulin G antimycobacterial antibodies compared with control subjects. Furthermore, controls exhibited decreased production of IL-4 by PPD-stimulated cells. Multivariate discriminant and factor analyses demonstrated divergent patterns of immune reactivity against mycobacterial antigens. The association of IL-4 and immunoglobulin G antibody levels in patients, in contrast to the high reactivity to tuberculin, increased proliferation to PPD, and higher levels of IL-2 and gamma interferon observed in healthy controls suggested that most TB patients exhibit a TH2 pattern of immune responsiveness while tuberculin-positive healthy individuals have a TH1 pattern. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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