| Autor: |
Kleckner N; Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138., Weiner BM |
| Jazyk: |
angličtina |
| Zdroj: |
Cold Spring Harbor symposia on quantitative biology [Cold Spring Harb Symp Quant Biol] 1993; Vol. 58, pp. 553-65. |
| DOI: |
10.1101/sqb.1993.058.01.062 |
| Abstrakt: |
Many different aspects of chromosome pairing, meiotic and/or somatic, can be explained conveniently if the interactions between homologous chromosomes are unstable. Initial pairing interactions should involve very unstable contacts. Such interactions could go a long way toward bringing each pair of homologous chromosomes into a joint domain, free of ectopic associations and random entanglements with other chromosomes, and in a topologically acceptable relationship to the domains of other chromosome pairs. More generally, colocalization into topologically acceptable domains could be a useful way of defining the existence of "order" at early stages in pairing; this definition requires that chromosomes have in some way recognized and interacted with one another but does not require that they necessarily be in close apposition and/or that they be aligned along their entire lengths. At later stages, interactions between pairing chromosomes could be unstable but still reversible, either intrinsically or due to an active cell-directed process. Transient homologous interactions could also contribute to maintaining colocalization between homologous chromosomes through DNA replication. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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