| Autor: |
Fasola EL; Department of Laboratory Medicine, University of Minnesota, Minneapolis., Moody JA, Shanholtzer CJ, Peterson LR |
| Jazyk: |
angličtina |
| Zdroj: |
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 1994 May; Vol. 19 (1), pp. 57-60. |
| DOI: |
10.1016/0732-8893(94)90052-3 |
| Abstrakt: |
Treatment of serious enterococcal infection involves the use of penicillin-aminoglycoside combination therapy if the aminoglycoside minimum inhibitory concentration (MIC) is < or = 2000 micrograms/ml, and the organism is susceptible to penicillin or ampicillin. We evaluated killing of 15 enterococci that differ in their susceptibility to gentamicin using time-kill studies at different gentamicin concentrations. Sensitive strains had a uniform population killed by gentamicin concentrations equal to or above the MIC. Low-level resistant strains (MIC > or = 8 but < or = 2000 micrograms/ml of gentamicin) had a diverse population with large numbers of cells killed at one-half the MIC, while the highly resistant strains (MIC > 2000 micrograms/ml) showed no killing by any concentration of gentamicin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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