[Milrinone decreases the positive inotropic response of heart muscle to izadrin].
| Autor: | Bardamova IB, Afanas'ev SA |
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| Jazyk: | ruština |
| Zdroj: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1994 Jul-Aug; Vol. 57 (4), pp. 29-31. |
| Abstrakt: | The interaction of the cAMP-phosphodiesterase inhibitor milrinone and the beta-adrenoceptor agonist isoproterenol was studied on guinea-pig isolated hearts. Milrinone, (10 microns) caused a positive inotropic response which differed from that of isoproterenol (7 nM) and decreased cardiac inotropic responses to the subsequent administration of isadrin despite a significant great rise in cAMP. The interaction of the drugs is assumed to be associated with the milrinone-induced increase in cGMP which is able to restrict myocardial cAMP-activated processes. |
| Databáze: | MEDLINE |
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