Surveillance in Lynch syndrome: how aggressive?
| Autor: | Lanspa SJ; Department of Internal Medicine, Creighton University, Omaha, Nebraska., Jenkins JX, Cavalieri RJ, Smyrk TC, Watson P, Lynch J, Lynch HT |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of gastroenterology [Am J Gastroenterol] 1994 Nov; Vol. 89 (11), pp. 1978-80. |
| Abstrakt: | Objective: To identify colorectal cancers occurring after colonoscopic screening in patients at risk for Lynch syndrome. Methods: All cancers in Lynch syndrome families on file at the Creighton University Hereditary Cancer Institute were reviewed for history of prior colonoscopy. Results: Of 225 individuals with 313 colon cancers, six patients from different families had colon cancers arising within 4 1/2 yr of colonoscopic surveillance. Another 17 patients had metachronous colon cancers within 5 yr of resection of their first colon cancer. Conclusion: Of 225 colorectal cancer patients from Lynch syndrome families, 10.2% of patients had colorectal cancer within 5 yr of colonoscopy or colon resection. In Lynch syndrome, the potential for interval neoplasms and the malignant potential of missed diminutive adenomas may differ from cases in the general population. |
| Databáze: | MEDLINE |
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