| Autor: |
Steinberg DA; Natural Products Research Section, American Cyanamid Company, Pearl River, New York., Bernan VS, Montenegro DA, Abbanat DR, Pearce CJ, Korshalla JD, Jacobus NV, Petersen PJ, Mroczenski-Wildey MJ, Maiese WM, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1994 Aug; Vol. 47 (8), pp. 887-93. |
| DOI: |
10.7164/antibiotics.47.887 |
| Abstrakt: |
The new glycothiohexide antibiotics, which are related to nosiheptide, were identified in fermentations of an actinomycete belonging to the genus "Sebekia". Strain LL-14E605 was classified as a "Sebekia" based on the presence of both mesodiaminopimelic acid and madurose in the cell wall and the presence of pseudosporangia encasing the spores. Culture LL-14E605 was successfully fermented in 10 to 3,000 liters of a complex medium. Antibiotic activity closely followed cell mass accumulation and usually peaked after 4 to 5 days of incubation. Glycothiohexide alpha demonstrated excellent in vitro activity against Gram-positive bacteria with MICs of 0.03 to 0.06 microgram/ml against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. However, glycothiohexide alpha failed to protect mice against a lethal challenge with Staphylococcus aureus Smith unless it was administered prior to challenge. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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