| Autor: |
Owen RH; Department of Microbiology and Immunology, University of Leicester, UK., Boulnois GJ, Andrew PW, Mitchell TJ |
| Jazyk: |
angličtina |
| Zdroj: |
FEMS microbiology letters [FEMS Microbiol Lett] 1994 Aug 15; Vol. 121 (2), pp. 217-21. |
| DOI: |
10.1111/j.1574-6968.1994.tb07101.x |
| Abstrakt: |
Cell binding of pneumolysin to target cells is an important step in the lysis of cells by this toxin. We sought to locate the cell-binding region of pneumolysin. Deletion of the six C-terminal amino acids decreased cell-binding activity by 98%. Furthermore, mutagenesis of an amino acid near the C-terminus decreased the cell-binding activity of full-length pneumolysin by 90%. The C-terminus of pneumolysin has an important role in cell-binding activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text