Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation.

Autor:	Soon-Shiong P; St Vincent Medical Center, Los Angeles, CA 90057., Heintz RE, Merideth N, Yao QX, Yao Z, Zheng T, Murphy M, Moloney MK, Schmehl M, Harris M, et. al.
Jazyk:	angličtina
Zdroj:	Lancet (London, England) [Lancet] 1994 Apr 16; Vol. 343 (8903), pp. 950-1.
DOI:	10.1016/s0140-6736(94)90067-1
Abstrakt:	Identification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate high in guluronic acid. We report insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Encapsulated human islets were injected intraperitoneally in a diabetic patient with a functioning kidney graft. Insulin independence with tight glycaemic control was demonstrated 9 months after the procedure. These results warrant a trial of a high dose of encapsulated islets in early-onset diabetic patients.
Databáze:	MEDLINE
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