| Autor: |
Medvedkin VN; Institute of Protein Research, Russian Academy of Science, Pushchino, Moscow Region., Klimenko LN, Mitin YV, Kretsinger RH, Shabanowitz J, Zabolotskikh VF, Podgornova NN |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of peptide and protein research [Int J Pept Protein Res] 1994 Nov; Vol. 44 (5), pp. 477-84. |
| DOI: |
10.1111/j.1399-3011.1994.tb00185.x |
| Abstrakt: |
p-Chlorotetrafluorophenyl (Tfc) esters of protected amino acids and peptides are more reactive than are the well known pentafluorophenyl (Pfp) esters. Two reagents, p-chlorotetrafluorophenyltrifluoroacetate (Tfc-OTfa) and di-(p-chlorotetrafluorophenyl)carbonate (di-Tfc-carbonate), can be used for their syntheses, thereby avoiding use of the allergic dicyclohexylcarbodiimide. This is especially important for bulk preparations. Many Fmoc- and Boc-amino acid-OTfc esters have been synthesized and characterized. The hexadecameric tandem repeat H-(AlaAlaLysPro)4-OH was synthesized using di-Tfc-carbonate for the preparation of Tfc-esters. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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