| Autor: |
Rojo J; Banco de Sangre, Hospital General de Mexico, Universidad National Autonoma, D.F. Mexico., Ferrer Argote VE, Klueppelberg U, Krueger GR, Eidt E, Ablashi DV, Luka J, Tesch H |
| Jazyk: |
angličtina |
| Zdroj: |
In vivo (Athens, Greece) [In Vivo] 1994 Jul-Aug; Vol. 8 (4), pp. 517-26. |
| Abstrakt: |
Fifty patients with various hyperplastic and malignant lymphoproliferative diseases were investigated for evidence of human herpesvirus-6 infection. Virus DNA and antigen expression was investigated in lymph node biopsies by in situ hybridization and immunohistology and was correlated with data of immunophenotyping. Supplemental immunoglobulin- and T cell receptor gene rearrangement studies were used to support the classification of the proliferative lymphoid lesion. Elevated numbers of cells carrying HHV-6 DNA and/or antigens were found in cases of Hodgkin's lymphoma and follicular center cell non-Hodgkin's lymphoma as well as atypical polyclonal lymphoproliferation (APL), yet not in reactive lymphoid hyperplasia and in most other lymphomas. Immunophenotyping showed that virus -infected cells were primarily lympho-histiocytic elements, less frequently Hodgkin's- and Reed-Sternberg cells, and not malignant B lymphocytes as in follicular center cell lymphomas. This suggests that the virus is rather not the causative oncogen in these cases, yet does not exclude a cocarcinogenic effect of it during the development and ths course of uncontrolled lymphoproliferation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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