| Autor: |
Strecker G; Laboratoire de Chimie Biologique, Centre National de la Recherche Scientifique n. 111, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France., Wieruszeski JM, Fontaine MD, Plancke Y |
| Jazyk: |
angličtina |
| Zdroj: |
Glycobiology [Glycobiology] 1994 Oct; Vol. 4 (5), pp. 605-9. |
| DOI: |
10.1093/glycob/4.5.605 |
| Abstrakt: |
Several O-linked oligosaccharides of the jelly coat surrounding the eggs of Axolotl maculatum were analysed by 1H-NMR spectroscopy. The four major oligosaccharidealditols released by reductive beta-elimination display either the Lewisx (Lex) determinant or the sequence GalNAc(beta 1-4)[Fuc(alpha 1-3)]GlcNAc. This last structure has previously been characterized in allergenically active oligosaccharides isolated from the sea squirt H-antigen, and in the N-linked glycans of Schistosoma mansoni and human urokinase. It represents the major carbohydrate chain found in A. maculatum, the oviduct of which constitutes an excellent source of beta 1-4-acetylgalactosaminyl transferase activity. Moreover, the carbohydrate chains isolated from A. maculatum are quite different from those found in seven other amphibian species, in which the presence of species-specific material has been characterized. The role of carbohydrates appears more and more apparent during the fertilization process, and the diversity of the O-linked oligosaccharides supports such a biological role. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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