[Microcalorimetric study of the effect of mitoxantrone on chromatin DNA in vivo].

Autor: Monaselidze DR, Kalandadze IaL, Khachidze DG, Topuridze I
Jazyk: ruština
Zdroj: Biofizika [Biofizika] 1994 Nov-Dec; Vol. 39 (6), pp. 1004-8.
Abstrakt: The influence of antitumor drugs--mitocsantron on the chromatine of tumor cells spleen tissue of BALB/c-mice has been established. Two-stage denaturation process of chromatine in normal cells has been shown. The first stage--thermolabel domain can be described by the following transition parameters: Td1 = 72, delta Td1 = 6.2 degrees C, Qd1 = 36.5 J/g DNA; the second one-thermostable domain by Td2 = 83, delta Td2 = 9.0 degrees C kappa Qd2 = 58 J/g DNA.
Databáze: MEDLINE