| Autor: |
Cwikiel M; Department of Oncology, University Hospital Lund, Sweden., Persson SU, Larsson H, Albertsson M, Eskilsson J |
| Jazyk: |
angličtina |
| Zdroj: |
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 1995; Vol. 34 (1), pp. 83-5. |
| DOI: |
10.3109/02841869509093643 |
| Abstrakt: |
Cardiotoxicity is a serious but relatively unknown side-effect of treatment with 5-fluorouracil (5-FU). The underlying mechanism of 5-FU cardiotoxicity has not been defined. The aim of the present study was to determine whether hemorheological factors might in part explain 5-FU cardiotoxicity. Changes of blood and plasma viscosity, fibrinogen and hematocrit were studied in 11 patients treated by 5-FU. The study showed a decrease in blood and plasma viscosity during treatment with 5-FU, probably caused by a decrease of plasma fibrinogen. Reversible cardiotoxic effects were demonstrated in four patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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