Histidine and aspartate phosphorylation: two-component systems and the limits of homology.

Autor: Swanson RV; Division of Biology, California Institute of Technology, Pasadena 91125., Alex LA, Simon MI
Jazyk: angličtina
Zdroj: Trends in biochemical sciences [Trends Biochem Sci] 1994 Nov; Vol. 19 (11), pp. 485-90.
DOI: 10.1016/0968-0004(94)90135-x
Abstrakt: Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.
Databáze: MEDLINE