| Autor: |
Varnum BC; Amgen Inc., Amgen Center, Thousand Oaks, California 91320-1789., Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW, Trail G, Clogston C, Toso RJ, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Nature [Nature] 1995 Feb 16; Vol. 373 (6515), pp. 623-6. |
| DOI: |
10.1038/373623a0 |
| Abstrakt: |
The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer, encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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