| Autor: |
Dumitrescu M; Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie., Jucu V, Zaharia CN, Belu O, Rojanschi D, Diaconu C, Talos D, Panaitescu M |
| Jazyk: |
francouzština |
| Zdroj: |
Revue roumaine de virologie (Bucharest, Romania : 1990) [Rev Roum Virol] 1993 Jul-Dec; Vol. 44 (3-4), pp. 211-21. |
| Abstrakt: |
The LDH cytotoxicity test is able to emphasize the stabilisation of human embryo fibroblast membranes, in vitro, by two amphiphilic drugs: the metomidate and the thymolol. The membrane stabilisation is emphasized by the reduced LDH externalization as compared with the untreated cells. The use of the LDH test for the selection of some natural complexes or synthetic drugs with membrane stabilising and potential antiviral activity is proposed. The inhibition of LDH by metomidate was recorded, as decreasing of the enzyme activity with increasing metomidate concentration. This fact explains the known lactic acid accumulation, under metomidate treatment of human subjects. The use of metomidate in classical cancer treatment potentiation is proposed instead of lactate externalization inhibitors, already used for this aim. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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