| Autor: |
Chimirri A; Dipartimento Farmaco-Chimico, Università di Messina, Italy., Gitto R, Grasso S, Monforte AM, Zappalà M |
| Jazyk: |
angličtina |
| Zdroj: |
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1994 Oct; Vol. 49 (10), pp. 649-51. |
| Abstrakt: |
Several 1-[(arylidene)amino]adamantanes were synthesized and evaluated in vitro as antitumor agents against 60 human tumor cell lines. Some of these derivatives showed specificity for human leukemia cell lines and 1-[(2-bromobenzylidene)amino]adamantane (2) (NSC 631076-L), the most active compound, was selected by the Biological Evaluation Committee (BEC), for in vivo testing. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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