| Autor: |
Paul BD; Navy Drug Screening Laboratory, Norfolk, VA 23511-2597., Past MR, McKinley RM, Foreman JD, McWhorter LK, Snyder JJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of analytical toxicology [J Anal Toxicol] 1994 Oct; Vol. 18 (6), pp. 331-6. |
| DOI: |
10.1093/jat/18.6.331 |
| Abstrakt: |
During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at pH 5.2 and above, this periodate-mediated transformation of methamphetamine to amphetamine was observed only at pH 9.1 and above. Therefore, to avoid this transformation, a pH of 6.2 was used for the oxidative degradation of phenylpropanolamines. The excess periodate was then reduced with thiosulfate or ascorbic acid prior to the extraction of methamphetamine using a basic pH. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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