| Autor: |
Lambrechts AC; Department of Molecular Biology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands., Looijenga LH, van't Veer MB, van Echten J, Timens W, Oosterhuis JW |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of cancer [Br J Cancer] 1995 Jan; Vol. 71 (1), pp. 73-7. |
| DOI: |
10.1038/bjc.1995.15 |
| Abstrakt: |
The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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