Factors influencing between-laboratory variability of C-reactive protein results as evidenced by the Belgian External Quality Assessment(EQA) Scheme.

Autor: Devleeschouwer N; Institut d'Hygiène et d'Epidémiologie, Service de Biologie Clinique, Brussels, Belgium., Libeer JC, Chapelle JP, Struway CL, Gyssels C, L'Hoir A, Albert A
Jazyk: angličtina
Zdroj: Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 1994 Oct; Vol. 54 (6), pp. 435-40.
DOI: 10.3109/00365519409085467
Abstrakt: Based on results from the Belgian External Quality Assessment (EQA) Scheme, we studied the main factors affecting the between-laboratory variation of C-reactive protein determination. Participants using homogeneous systems with several calibration points generally achieved better performance. Working temperatures influenced the results to a lesser extent. The present study stresses the importance for EQA organizers to collect more detailed information about CRP analytical methods used by the participants. It also suggests that manufacturers should be more involved in the management of quality, in particular by striving for standardization of the material (kit and calibrator) they produce for CRP assay.
Databáze: MEDLINE